Maybe long after I had left, but during the time I played the most common questions to the top PvP / PvE players was "what macro(singular) do you use?"
Rift is an extreme example but my point still stands, macro's like these are, in my eyes, an exploit.
I pretty much setup my keyboard w/ my main skills 1-6, alt & shift 1-6 for alternate skills. Q, E, F & X for cooldown's usually.
I've played a healer and understand the importance and utility the mouse-over can provide. WoW had this coupled w/ Grid which made healing near trivial.