A few personal tip for key bindings in general:
> Make sure you are able to cast instant skills and strafe at the same time
- For example: if you strafe left with Q then don't bind an instant skill to 1.
> If you use the Ops UI to click targets then do not bind healing skills to your mouse. The main reason for this is because you cannot cast anything when your mouse cursor is hovering over specific UI frames such as the Ops UI, portraits or focus frame.
- BioWare really needs to reconsider this "bug" imo
> Improve customization: Override in-game keys which cannot be remapped (like left/right mouse clicks) by the use of additional software like AutoHotKey or a Key Mapper.
> Step out of the box and experiment new bindings, but bear in mind: re-arranging key bindings can be frustrating. It takes time to re-adjust yourself before you get comfortable with finding the right keys blindfolded.
> Use mnemonics to associate certain skills with a character. For example: R binds to Reactive Shield, A binds to Advance Medical Probe, K binds to Kolto Bomb etc...
Many people tend to use the same key configuration for all their games. If you play(ed) WoW for example - you prolly have a layout that is more or less the same