Well, organize. I have my skills laid out in an order. Right bar is for buffs and active abilities, top row from 1-5 are low-cooldown attacks, 6-9 are crowd control abilities, and then bottom row for 1-7 are for hotkey abilities and the rest are high-cooldown emergency abilities.
All nicely laid around my finger. For example E and Q are for retaliation and low-cooldown dps abilities, R-T-G are for defensive abilities, F-G-H-Y for situational abilities. Easy peasy.