I don't think I'd be able to play my Shadow without my Naga mouse.
Movement (turn with mouselook):
W-Fwd
A-Strafe Left
D-Strafe Right
S-Back
Abilities,Consumables,etc:
1-6
Shift 1-4
All Naga buttons
Q,E,R,X
Shift Q + E + R
` and Shift `
Shift Mwheel Up/Down
I used Astralfire's setup from the Handbook sticky and modified it to my liking. If you haven't looked at that yet, I'd start there.