For me, I find the default movement key binds to be junk. I rebind strafe left/right to a and d, freeing up q and e for important skills. Turn with your mouse, not your keyboard, by holding down the right mouse button and dragging the mouse.
I also rebind auto run to the clickable scroll wheel.
A lot of people also forego using the s key to "backpedal", in favor of using the s key for a skill. Never backpedal, it's slow and useless. Or so I've heard, lol. Old habits die hard for me. I don't backpedal per se, but I just like having the option if move to far forward. Usually only when I'm on a mount, though.
Some people forego using the keyboard at all to move, favoring holding down left and right mouse simultaneously for forward. Instead of backing up, they'll "run through" their target and swing the screen around with the mouse. But I'm not one of those people. I just never got used to it. Strafe rebind combined with holding the right mouse button works well enough for me.
F1 - F6, other f keys for lesser used skills/long cool downs/buff skill.
R,f,v,c,x,z are also good keys to rebind to skills.
All of this is, of course, just my own preferences. Your mileage may vary.
Cheers, and have fun!