I've tried a few different ways of keybinding, and found that this one JSharp Tutorials
is better for my playstyle.
There are sometimes where hitting the G13 buttons doesn't result in the action I wanted, and that's mainly to do with the location of what I have done with the quick binds, as I should have 6 default profiles, mele/ranged, then split to dps/heals/tanks since most classes have more or less the same amount of DCDs (barring Merc vs. PT for example) but once you've got the keybinds down, play about with them to find out what you prefer.
Then as suggested in the video, spend a few moments just moving around, platforming and generally changing directions, and I don't have a backwards key anymore as moving backwards is a wonderful way to die in PVP! Sorry <S~Key> for victory guys, my S key is grenade
A few moments in pve taking care of trash mobs and the like but to work your rotation or attack defense cool downs the bosses such as Bounty Hunter Kingpin's or the fractured can work to make your muscle memory better. And of course the more you practice no matter how you key bind the better you'll become.
Hope my ramblings on the topic helps