Yes ive lost a decent share of defense, base is 21.5%, dam reduction is 43%. With my previous setup my defense was around 24-25%, but my absorption and shield were much lower as well. I've noticed no problems so far diong HM EC, only downed Toth and Zorn. I take the toth beserk without going under 50% HP. Zorn I take more damage because i cant shield his attacks but it still goes smoothly.
Overall i love this setup, with campaign gear it'll only get better, keep similar stats just way more endurance.