I have seen this issue as well. Not always, but when it happens, it's incredibly annoying. 1. Hit a button for an ability. 2. Watch the CGD "timer" slide down all the hot buttons. 3. Wait even longer for the skill animation to finally begin. If it's an "instant" skill, it fires at this point, if it's a "timed" ability (like Charged Burst for Smuggler), this is when the timer for the ability will finally start. 4. Wait for skill animation to end, so hitting the next skill doesn't "interrupt" the one in progress. Repeat. Worse yet is when hitting the key for a skill causes the mob to "notice" my character and attack, while I'm still waiting for the skill (or skill timer) to start. Best workaround I've found for this (when soloing) is to always hit Ctrl+1 first, so my companion starts attacking. Not an option when you're in a group and companions are all dismissed. 1. Left click first mob to select it as "target", then hover cursor over second mob. 2. Hit Ctrl+1 to order companion to attack first mob, then click on second mob. 3. Click on a skill and watch the GCD run while waiting for skill to actually "fire" (or skill timer to start). 4. Hope step 3 ends before companion finishes off his current mob and moves on to my currently targeted one and kills it, too. 5. Try to target another mob before my companion kills them all and repeat steps 3 & 4. I haven't noticed that companions have this delay in skill activation. So while the companion automagically does all his/her/its skills without any delays, I muddle along, targeting mobs and hoping I get a skill or two to fire before my companion kills it.