I'm a level 39 Sith Warrior Juggernaut, and I've got so many different skills that my keyboard and 5 mouse keys don't suffice. I cope by not using some skills even though I should. I've got an AOE slowdown coupled with a high damage ability that only works on slowed mobs, but I never use either because I don't have enough buttons. This problem is turning me into a clicker! I activate my long cooldown abilities using the mouse not because I want to, but because I've got no more keys to bind them to. This is after I bound a bar to shift-1, shift-2, etc. and my mouse has 5 buttons, 3 of which I also bind shift variations to. It's hard to hit buttons 7, 8, 9 when my hand is already on button 1 so I sometimes activate a different ability than the one I want. I feel like I must be doing something wrong - this can't be the intended way to play the game, can it?
The game doesn't have a dps meter, so I can't tell if perhaps there are some skills I should never use based on my spec. As far as I can tell, every single ability I've got is useful in some circumstances and those circumstances all pop up because many mobs in this game do things like CC'ing you or heal themselves (calls for interrupts).
If you are playing a Sith Warrior Juggernaut, or if your class has a similar skill proliferation problem, how do you cope? Is this game really intended to be played with a 10-button mouse?
Edit: I've also bound the tilde button and shift-tilde.
Edit: From reading this and talking to my guild, here's some tips that are currently working much better for me now. First of all, you don't need strafe keys since holding down right mouse button will make your keyboard turn keys strafe. So rebind q and r to turn, and use A and D for something else (and of course shift-A and shift-D). Rebind "chat response" from R to [ and use R and shift-R for something else. F gets you in cover. If you need that, you can still use shift-F. You can also bind to mouse scroll up and down, including shift versions. Also use tilde and shift-tilde (the key before 1 on your keyboard). That's been enough keys for me so far.