Are you using your mouse or your keyboard to select your abilities?
Do you have ability queuing turned up (Preferences > Controls > Combat) to higher than the default 0.5?
Are you using your interrupt? If a blue bar starts growing above your opponent's health bar, use your interrupt to get rid of it. It will stop their uber damage abilities.
Are you attacking and letting your companion follow up, or are you sending them in to get aggro so you can survive longer?
Are you making use of environmentals (the pulsing red arrows pointing at canisters that, when clicked on, will explode and help you in your fight, if not kill them outright)?
Are you making use of level appropriate healing packs?
Are you using class appropriate stims?
Food for thought.