If you were facing 3 dps and 1 healer, who would you target first? Probably the healer, and then focus down the dps.
What if one of those DPS was suddenly a tank, with guard on that healer, effectively giving the healer double HP?
It takes a lot of damage to burn through a guarded healer (usually 33k or so health, assuming they have 16-17k health normally), in which time they can heal themselves, and the dps can kill you.
If they target the dps, the tank can just move the guard, causing the same problem, and/or the healer can help negate a lot of that damage.
Taunts also cause a lot less damage to be taken as well.
So, you could target the tank, which IMO may actually be the "best" choice, as without a guard on them tanks technically have less health than the other members of the group with a guard, and without taunts you do the most damage to them.
The problem here is that even without guard a good tank will have 18k-22k health, defensive cool-downs, and generally take less damage with armor and defensive talents that reduce damage taken.
So, attacking the tank still takes a long time, and the whole time you still have the dps chewing at you, and the healer healing the tank.
Tanks also do relatively decent damage, so that with their defensive abilities and larger health pools can usually go 1v1 with most other people if needed.
A healer and a tank can hold a door or turret for a painful amount of time, allowing enough time for help to arrive, or other things to be accomplished elsewhere on the battlefield.