Been using the Naga since my days in lotro, then wow, rift, and now here. It's been working quite well for me throughout. Keys 10, 11, and 12 are a bit of a stretch to reach, but not bad at all. LOVE having access to so many buttons on hotkey, VERY efficient, and no reliability problems whatsoever. Soon after you start using it, you won't even notice your mouse has 17 different buttons, plus the mouse wheel; should feel second nature rather quickly. I have averaged sized hands for a guy, I'd reckon, so I don't know how the device would pan out for someone with larger hands. Also, I agree with the above poster who recommended pairing with a G13 if you can afford both. Provides a metric TON of buttons so you can have virtually *everything* hotkeyed. Awesome, esp for fast-paced pvp.