If your mouse has any extra buttons on it figure out how to set them to something else. Such as your forward and back buttons, set them to modifiers (Alt, Shift, Control<can mess with **** stick with shift and alt). Even the microsoft peripherals on my other computers have the ability to modify button usage based on the program that is running. Just have to get the intellipoint software.
If you have movement keys still bound to Q and E undbind them and Learn to use them as keybinds. First character I have ever played that required me to do this. Now I have gotten used to it and use it for everything I play. Your gaming will improve for learning to make use of those extra keybinds.
With the use of keys 1-6 Q and E coupled with the modifiers Shift and Alt you have a plethora of options. If you can bind your modifiers to your mouse not only do you have a plethora of options but they are easily accessible as well.
I also have things bound to R F C X and Z add that up with modifiers and we are looking at even more tools quickly available.
Most keybinds I have ever had to make use of and I use 90% of them actively. It is a learning curve but if you can make it work your future MMO gaming will improve for it.
Hope that helps some.