I am a console gamer who could not get comfortable using keyboard bindings and got the Nostromo and Naga and found they work great. But as other posters stated above you have to get used to what works best for you, as each person is different in that regard.
When I set up the Nostromo the movement keys were already binded to the thumbstick correctly, so you should be good there. Make sure you open all four quick slots and then bind the quickslots in game as the poster suggested above with the main bar already being 1-12, and the additional quick slot bars can be something like shift 1-12, Control Shift 1-12, Etc.
What I did was I use the Naga for quickslots 1 to 12, and when I want to access a different quick slot I programmed the Nostromo as follows: key 5 Tab (for targeting) key 4 Shift, which allows me access to the 1-12 keys that are binded with shift. I just hold down key 4 on the Nostromo and then hit 1-12 on the Naga for the skills bound on those quickslots. Key 3 control shift, for those quickslot bindings, key 2 Ctrl for controlling your companion, and key 1 with alt shift for my least used quickslot abilities, as key 1 is farthest from my natural hand resting position.
Be careful with using alt shift, as I found that if I am using those quickslot abilities and have key 1 held down, and decide to target another mob this gets recognized as alt tab, and pops me out of the game into windows.
This helped me greatly and feels intuitive to me. The other buttons you can program however works best for you. If you are a healer you may want to program buttons 7-10 on the Nostromo as targeting party members for example. Just look at what button on the keybindings target party member (I think it might be F1 to F4) and then program 7-10 with those keys.
I also play a cover class and programmed the 2 buttons directly above and below the thumbstick as take cover and take cover in place, as you have to stop moving to do that anyway. Everything else is programmed between the Nostromo and the Naga and I only use the keyboard now to chat, and can use every ability available.
This may help to start, but in the end it will be what feels most natural to you, so make sure you experiment with getting the right setup.