I went ahead and changed mine last night before crashing in bed.
I now use 1-5, shift 1-5, qerfc, shift qerfc and the mouse buttons
Basically, I unbound my turn left and right keys and moved strafe left and right to them since I never turn with the keyboard (FPS player). I bound Q to Force Charge and R to Smash, with E as Scream. F is Retailation and C is Backhand.
Shift + Q is Force Throw, E is Choke, R is Enrage, F is pommel strike
Mousewheel up and down are change targets prev and next. Alt+mousewheel is camera zoom. Shift+up and down are select friendly targets
Mousewheel click is steamy regen.
Mouse 4 and 5 are Taunt and Threatening Scream
Tab gets me out of roots.
Shift + space throws the huttball <--Honestly my favorite decision. Next to mwheel selection.
I looked into the naga, damn that's a fine looking mouse. I'll stick with my MX518 though until I can justify the cost
It's going to take me a level or so to get used to it, but it already feels WAY more comfy than before. Maybe it's the fps player in me, having bound a load of keys around esdf... wait... I should move my movement to esdf and open up qaz.... maybe later, but it looks like this is plenty of binds for now