It depends entirely on what type of mobs I'm fighting as to what I open with. I usually open with death field, followed by slam( or whatever its called) Then I pick a target and use shock..then assassinate. If they are stronger, I throw in thrash, use crushing darkness when its an instant attack, and stun and use tumult/assassinate. For boss mobs, I want Ashara to get aggro, so I open with all my DoTs/interupts..melee and repeat. The idea is to pull aggro from her before she dies, but not too soon or they will kill me. Ashara isn't the most ideal companion, but I like her the best, so I make due... I just turned 40, so I got my top tier talent. I will open with that, then death field from now on.