This is how I play the game, which works best for Me. Maybe it will/won't for you.
- All abilities have shortcuts on my bars. (You can set it so it shows all for action bars (lower middle, left, right and the default middle) in Interface tab of preferences in the escape menu)
- To add shortcuts see the Shortcut tab (bottom of the escape menu) > Quickslot features.
- I also change my movement strafe left and right to 'A' and 'D', why because I play with my Rightclick held in all the time to move my camera around.
- I set my interface preferences to auto target closest when I do an action move.
So that's my setup.
Then I just proceed to move with wasd while controlling the direction with my camera (holding rightclick and moving the mouse).
I target with TAB, which cycles the target starting with the closest, and hit them with the shortcuts. (As stated above there is no auto-attack so keep hitting that shortcut)
I only let go of that when interacting with npc or when I need to target a specific target in a crowd.
Hope it helps!