Certainly.
To some extent, however the mass of the ship itself would factor in.
Depending upon how much of the ships motion is dependant upon the main engines it may or may not be able to yaw/pitch/roll or even slow itself down.
In fact to say there is no resistance in space is itself not entirely accurate.
Space is not entirely empty, nor void of 'forces' that may act upon a vessel. "Solar wind", various radiation sources, random particles, debris, the effect mistakenly reffered to as "gravity", can all have an effect on an objects trajectory in relation to another.
Think of it like an average wave breaking acrost the hull of an aircraft carrier. The ship is going to move, but it is so massive that such movement is so slight that it cannot be felt, much less seen.