When you foray into the world of keybinding, you are entering a whole new gaming world. You are become more then a casual gamer, you are becoming a solid gamer. Every program, every game, everything you do with a computer has keyboard shortcuts. When you start to utilize that, everything you do with a computer starts to become more efficient. So, how do you do that? One answer is muscle memory. It is going to be hard no matter what you bind and how you bind it. It will feel awkard and it will feel weird. The best advice I can give to help facilitate the transition is to stop using the keyboard for any kind of movement right now, as soon as you read this. Only use the mouse. Don't strafe, don't push forward on your W key, just use your mouse. As you start to get the hang of this, you will quickly realize how fast your left hand feels completely and utterly useless. It needs something to do! Queue the bindings. Some use a hybrid system of Q,E,Z,X,C with alternate forms of Alt, Cntrl and Shift to bind the important spells that you use. Others scrap the movement keys altogether, (such as myself) and in my case, I work with, Q,W,E,R,T,A,S,D,F,G,Z,X,C,V and bound every spell in the game with this basic layout using alt, Cntrl and shift. Attack spells, I use the regular keys, support spells are Cntrl + keys, non combat spells are Alt + keys and companion, etc spells are Shift + keys, but this works for me. (Used to using grid on Starcraft.) So.... Whatever works for you, however you bind, whatever you do, the only reason you do it is because you want your left hand to be pressing buttons instead of 'clicking spells.' How deep you go is how well you can effectively keep your character mobile with just the mouse.