Hmmm, I don't know, game mechanics and plot require us to fight big beasts and sith lords with our fists which to me in all truth only against big beats it seems ridiculous.
But punching jedi and sith in the face, that could happen. My scoundrel is a cyborg so i'd imagine him to be enhanced. Keeping their saber busy with your blaster while you go in for a hook... I can see that happening tbh.
Inbetween, throwing flash bombs, and thermals, using shield generators and being accurate with a blaster is enough to overwhelm any regular sith lord or Jedi knight.
HK-47 does make a good case on how to kill jedi in Kotor with overwhelming them.
Just remember, Jedi and Sith are over confident within their abilities which gives us the upper hand in terms of allowing them to underestimate us for the surprise attack.
They use the force to speed up their reflexes, we use stims.
Don't believe the jedi and sith hype Cowboy.