I am certainly going to buy ME3, be it at launch or later, but I'm concerned it might go the way of DA2.
The addition of multiplayer is detestable to me. Sure, Bioware can walk and chew gum at the same time, but I can't help but feel it's going to be an atrocious waste of time. I like some of the things they did with ME2's combat but it should never be the focus of the game, and never in lieu of exploration and character development.
ME2 had great combat compared to ME1, but like SWTOR it was practically on-rails. I'm worried they might take the same approach here and dumb down the RPG elements even more.