I was a clicker for the longest time as well. I've been playing MMOs since EQ launch, but never took the time to keybind until i had to when i played my first healer in Rift.
Fast forward to now. I picked up a Razer Naga a few months ago and it quite literally changed the way i play MMOs. I have every single ability mapped to a 1 to = key (or modifier + key.) My hand only leaves my mouse to type.
I still use wasd to move around as well, but my keyboard hand almost never leaves those 4 keys. Moving my pinky for a Shift or Ctrl modifier is about as much as my left hand moves when in combat. I can do everything else with my right hand. Talk in vent, select a convo dialog option, heal, switch hotbars to DPS, emergency target switch, start a fraps recording, etc.
I could never go back to being a clicker. I've seen the light.